STUDY IDENTIFIES KEY HUMAN GENE THAT PROTECTS AGAINST AVIAN FLU

July 17th, 2023.

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An international study led by scientists at the MRC-University of Glasgow Centre for Virus Research (CVR) has found a key human gene responsible for blocking most avian flu viruses from spilling over into people.

The study into the pandemic potential of avian flu, identified the human gene BTN3A3, which is commonly expressed in our airways, as a key human defence against avian flu. Through a series of extensive tests, the study team were able to show that the BTN3A3 gene is vital to protecting humans against avian flu, as most strains of the virus cannot get past its defences.

Since 2022 there has been a rise in bird flu cases around the world in both domestic and wild birds. While the disease mainly affects birds, it has been known to spill over into other species, including, in rare cases, humans. For example, the 1918 Spanish flu virus which caused more than 25 million deaths worldwide is believed to have originated from an avian strain.

However, experts agree there are still several gaps in our scientific knowledge that make it difficult to be able to predict which variant of avian influenza virus might spill over into the human population and when.

You can read more about the study on the University of Glasgow website.

The study, ‘BTN3A3 evasion promotes the zoonotic potential of influenza A viruses’ is published in Nature.

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